That's a big question
First, this is a wordpress based site so get familiar with wordpress, it's brilliant. Next, the shop is simply feed based with upfront info to make it interesting. So, you need to understand php or asp and you need to write the code to get visitors buying: I guess you can't do that, so you need a good databased system. I assume (never assume), you know how to build and host a website. So, you need a way to display the feeds. I have looked at others but, I do favour http://www.pricetapestry.com/ for it's ease of use and support.
Have a look at one of my sites which is similar to etoys and utilises both wordpress and price tapestry -
The affiliate lifestyle is not easy and the hours are long but, it is enjoyable so keep trying and you will succeed.